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Introducing LacriFill Hyaluronic Acid (HA) Gel Punctal Plug

Apr 21, 2025

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Introducing LacriFill Hyaluronic Acid (HA) Gel Punctal Plug

What is Lacrifill?

Lacrifill is a novel, FDA-cleared canalicular gel punctal plug made from cross-linked hyaluronic acid (HA). Designed to treat dry eye disease, it offers a modern alternative to traditional punctal plugs by providing a comfortable, effective, and longer-lasting solution for tear retention.

How Does It Work?

Lacrifill is injected into the punctum, filling the canaliculus with a soft yet robust HA gel that conforms to the anatomy and fully occludes tear drainage.
 
- The cross-linked HA gel is biocompatible and resists degradation, allowing it to last up to 6 months—longer than most dissolving plugs.
 
- The procedure is quick, performed in-office with minimal discomfort (one drop of anesthesia).

Why choose Lacrifill?

Material: cross-linked hyaluronic acid 
Duration: lasts up to 6 months 
Comfort: Highly comforming, soft gel
Removal: Easily irrigated (if needed) 
Placement: simple, in-office procedure
 
*Advantages: No foreign body sensation, will not fall out, naturally dissolves, increases tear volume/reservoir, biocompatible, safe, and FDA-approved.

Clinical Results

- Studies show Lacrifill is at least as effective as leading plugs (like Oasis Form Fit), with statistically significant improvements in tear production, corneal staining, and tear breakup time at 3 and 6 months.
 
- Patients report high comfort and satisfaction, with minimal risk of irritation, infection, or dislodgement.

Who Can Benefit?

- Patients with dry eye symptoms not relieved by artificial tears or other therapies.
 
- Those preparing for or recovering from cataract, glaucoma, or refractive surgery.
 
-Patients with corneal staining
 
- Anyone seeking a longer-lasting, low-maintenance solution for dry eye relief.
 
-Patient diagnosed with aqueous deficient dry eye disease

Conclusion

Lacrifill HA Gel Punctal Plug represents a paradigm shift in dry eye management—combining the natural benefits of hyaluronic acid with innovative delivery for superior patient outcomes. Ask your dry eye specialist if Lacrifill is right for you and experience the next level in dry eye care.
 
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Sources:
 
 
[3] Cross-linked hyaluronic acid gel occlusive device for the treatment of dry eye syndrome https://pmc.ncbi.nlm.nih.gov/articles/PMC6231461/
 
[4] Effectiveness and safety of a novel crosslinked hyaluronate canalicular gel occlusive device for dry eye https://pubmed.ncbi.nlm.nih.gov/38875184/